Tips to improve IVF Surrogacy Success

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Summary:
Best surrogacy useses a straightforward IVF cycle in which the surrogate mother takes fertility medication to stimulate her ovaries the eggs are retrieved and fertilized with the fresh sperm of the male partner from the couple of intended parents whose desiring pregnancy. Created...

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High frequency of EGFR mutations found in Asian population

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Adenocarcinoma histology, female sex, never-smoking status, and Asian ethnicity have been considered the most important factors associated with EGFR mutations in non-small cell lung cancer and response to EGFR inhibitors. A recent study has found that, within the Asian population, the frequency of EGFR mutations associated with other demographic and clinical characteristics is higher than previously reported, even in patients with a history of smoking, suggesting that mutation testing should be done on a broader basis among Asian patients with advanced adenocarcinoma of the lung.The PIONEER study is the first prospective, multinational epidemiologic study to document the frequency of EGFR mutations in lung adenocarcinoma in the Asian population. The PIONEER authors found that EGFR mutations were present in 51.4% of stage IIIB or IV adenocarcinomas of the lung among 1,450 patients from seven regions of Asia. Previous reports have suggested a frequency of approximately 30% among the Asian population (compared with 20% among the white population). The findings of the PIONEER study are published in the February issue of the International Association for the Study of Lung Cancer’s journal, the Journal of Thoracic Oncology (JTO).The frequency of EGFR mutations was high among women (61.1%) and never-smokers (60.7%), but EGFR mutations were also common among men (44%), occasional smokers (51.6%), and previous smokers (43.2%). With regard to Asian regions, the frequency was highest in Vietnam (64.2%) and lowest in India (22.2%).”The frequency of EGFR mutations in demographic and clinical subgroups of Asian patients in PIONEER suggests that EGFR mutation testing should be considered for all patients with stage IIIB or IV adenocarcinoma of the lung in Asian populations,” says first author Yuankai Shi, MD, of the Department of Medical Oncology, Cancer Institute/Hospital, Beijing, China. More widespread mutation testing would help to ensure the optimal identification and treatment of patients with lung adenocarcinomas that harbor EGFR mutations.Story Source:The above story is based on materials provided by International Association for the Study of Lung Cancer. Note: Materials may be edited for content and length.


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Promise for castor crop planting in Florida

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Castor, grown in Florida during World War II and currently considered as a component for military jet fuel, can be grown here again, using proper management techniques, a new University of Florida study shows.Those techniques include spacing plants properly and using harvest aids to defoliate the plant when it matures.Growers in the U.S. want to mechanically harvest castor, which is typically hand-picked in other parts of the world, the researchers said. Among other things, the UF/IFAS study evaluated whether the plant would grow too tall for mechanical harvesting machines.Castor oil is used in paints, lubricants and deodorants, among other industrial products, said David Campbell, a former UF agronomy graduate student and lead author of the study. It has not been grown in the U.S. since 1972, because the federal government ceased giving price supports, the study says.At UF research units in Citra and Jay, scientists tested Brigham and Hale, two types of castor that were bred in an arid part of west Texas near Lubbock in 1970 and 2003, respectively. These cultivars are shorter than castor found in the wild, said Diane Rowland, an associate professor of agronomy at UF’s Institute of Food and Agricultural Sciences, and Campbell’s faculty adviser.Scientists tried to control the growth of the plants even more by spraying them with a chemical, she said. Even though the crop didn’t respond to the chemicals, it did not grow taller than expected. So it appears these types of castor can be harvested mechanically, she said.While yields were lower than those reported in Texas research trials in 1993, results are promising for Florida.“We were concerned that, in this environment, with all the moisture and the good growing conditions, that it would grow too tall. But it didn’t,” Rowland said. “So it shows that shorter genetic types will still work, without the chemical application. …


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