Molecular aberration signals cancer: Role of small non-coding RNAs in protein production, cancer cells

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Several scientists, including one at Simon Fraser University, have made a discovery that strongly links a little understood molecule, which is similar to DNA, to cancer and cancer survival.EMBO reports, a life sciences journal published by the European Molecular Biology Organization, has just published online the scientists’ findings about small non-coding RNAs.While RNA is known to be key to our cells’ successful creation of proteins, the role of small non-coding RNAs, a newly discovered cousin of the former, has eluded scientific understanding for the most part. Until now, it was only surmised that most of these molecules had nothing to do with protein production.However, scientists at SFU, the University of British Columbia and the B.C. Cancer Agency have discovered that many non-coding RNAs are perturbed in cancerous human cells, including breast and lung, in a specific way. The disturbance, which manifests itself as shorter than normal molecular messaging, also occurs at a specific spot on genes.”These two identifiable characteristics give cancer-causing non-coding RNAs a chemical signature that makes it easy for scientists to identify them in the early stages of many different types of cancer,” says Steven Jones.The SFU molecular biology and biochemistry professor is this study’s senior author, and the associate director and head of bioinformatics at the B.C. Cancer Agency’s Genome Sciences Centre.”These molecules’ existence can also be used to classify cancer patients into subgroups of individuals with different survival outcomes,” adds Jones. “While the precise reason why a tumor would change the behaviour of genes in this way is not known, it is likely that it represents a mechanism by which the cancer can subvert and takeover the normally well controlled activity of our genes.”This study uncovered non-coding RNAs’ cancerous role by using high-throughput sequencing techniques to analyse reams of genetic information on normal and diseased tissue as part of the Cancer Genome Atlas project.The Cancer Genome Atlas is an ambitious project to characterize the genetic material of more than 500 tumors from more than 20 different cancers. The project provides a goldmine of data for bioinformaticians such as Jones.Story Source:The above story is based on materials provided by Simon Fraser University. Note: Materials may be edited for content and length.


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Four unknown galaxy clusters containing thousands of galaxies discovered 10 billion light years from Earth

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Four unknown galaxy clusters each potentially containing thousands of individual galaxies have been discovered some 10 billion light years from Earth.An international team of astronomers, led by Imperial College London, used a new way of combining data from the two European Space Agency satellites, Planck and Herschel, to identify more distant galaxy clusters than has previously been possible. The researchers believe up to 2000 further clusters could be identified using this technique, helping to build a more detailed timeline of how clusters are formed.Galaxy clusters are the most massive objects in the universe, containing hundreds to thousands of galaxies, bound together by gravity. While astronomers have identified many nearby clusters, they need to go further back in time to understand how these structures are formed. This means finding clusters at greater distances from Earth.The light from the most distant of the four new clusters identified by the team has taken over 10 billion years to reach us. This means the researchers are seeing what the cluster looked like when the universe was just three billion years old.Lead researcher Dr David Clements, from the Department of Physics at Imperial College London, explains: “Although we’re able to see individual galaxies that go further back in time, up to now, the most distant clusters found by astronomers date back to when the universe was 4.5 billion years old. This equates to around nine billion light years away. Our new approach has already found a cluster in existence much earlier than that, and we believe it has the potential to go even further.”The clusters can be identified at such distances because they contain galaxies in which huge amounts of dust and gas are being formed into stars. This process emits light that can be picked up by the satellite surveys.Galaxies are divided into two types: elliptical galaxies that have many stars, but little dust and gas; and spiral galaxies like our own, the Milky Way, which contain lots of dust and gas. Most clusters in the universe today are dominated by giant elliptical galaxies in which the dust and gas has already been formed into stars.”What we believe we are seeing in these distant clusters are giant elliptical galaxies in the process of being formed,” says Dr Clements.Observations were recorded by the Spectral and Photometric Imaging Receiver (SPIRE) instrument as part of Herschel Multi-tiered Extragalactic Survey (HerMES). Seb Oliver, Head of the HerMES survey said: “The fantastic thing about Herschel-SPIRE is that we are able to scan very large areas of the sky with sufficient sensitivity and image sharpness that we can find these rare and exotic things. …


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America"s natural gas system is leaking methane and in need of a fix

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The first thorough comparison of evidence for natural gas system leaks confirms that organizations including the Environmental Protection Agency (EPA) have underestimated U.S. methane emissions generally, as well as those from the natural gas industry specifically.Natural gas consists predominantly of methane. Even small leaks from the natural gas system are important because methane is a potent greenhouse gas — about 30 times more potent than carbon dioxide. A study, “Methane Leakage from North American Natural Gas Systems,” published in the Feb. 14 issue of the journal Science, synthesizes diverse findings from more than 200 studies ranging in scope from local gas processing plants to total emissions from the United States and Canada.”People who go out and actually measure methane pretty consistently find more emissions than we expect,” said the lead author of the new analysis, Adam Brandt, an assistant professor of energy resources engineering at Stanford University. “Atmospheric tests covering the entire country indicate emissions around 50 percent more than EPA estimates,” said Brandt. “And that’s a moderate estimate.”The standard approach to estimating total methane emissions is to multiply the amount of methane thought to be emitted by a particular kind of source, such as leaks at natural gas processing plants or belching cattle, by the number of that source type in a region or country. The products are then totaled to estimate all emissions. The EPA does not include natural methane sources, like wetlands and geologic seeps.The national natural gas infrastructure has a combination of intentional leaks, often for safety purposes, and unintentional emissions, like faulty valves and cracks in pipelines. In the United States, the emission rates of particular gas industry components — from wells to burner tips — were established by the EPA in the 1990s.Since then, many studies have tested gas industry components to determine whether the EPA’s emission rates are accurate, and a majority of these have found the EPA’s rates too low. …


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